Kidney transplantation is the standard procedure for the treatment of end-stage renal
disease (ESRD). During kidney storage and before implantation, the organ is exposed to …

Background. Apoptosis contributes to the severity of ischemia-reperfusion injury (IRI),
limiting the use of extended criteria donors in liver transplantation (LT). Machine perfusion …

The liver is a highly vascularized organ where fluid properties, including vascular pressure,
vessel integrity and fluid viscosity, play a critical role in gross mechanical properties. To …

Normothermic ex vivo liver perfusion (NEVLP) is a novel system for organ preservation that
may improve over static cold storage clinically and offers the chance for graft modification …

Background. Normothermic machine perfusion (NMP) is used to preserve and test donor
livers before transplantation. During NMP, the liver is metabolically active and produces …

The aim was to optimize the perfusate composition by including a hemofiltrator to the
PhysioHeartplatform for ex situ heart perfusion of porcine slaughterhouse hearts. Fourteen …

Background Considering the expected increase in the elderly population and the growing
emphasis on aging-related biomedical research, the demand for aged laboratory animals …

Introduction: The current liver organ shortage has pushed the field of transplantation to
develop new methods to prolong the preservation time of livers from the current clinical …

This protocol presents an optimized erythrocytes-free NEVLP system using mouse livers. Ex
vivo preservation of mouse livers was achieved by employing modified cannulas and …

In transplantation, livers are transported to recipients using static cold storage (SCS),
whereby livers are exposed to cold ischemic injury that contribute to post-transplant risk …