Recent methods of kidney storage and therapeutic possibilities of transplant kidney
Kidney transplantation is the standard procedure for the treatment of end-stage renal
disease (ESRD). During kidney storage and before implantation, the organ is exposed to …
disease (ESRD). During kidney storage and before implantation, the organ is exposed to …
Delivering siRNA compounds during HOPE to modulate organ function: a proof-of-concept study in a rat liver transplant model
E Bonaccorsi-Riani, AR Gillooly, S Iesari… - …, 2022 - journals.lww.com
Background. Apoptosis contributes to the severity of ischemia-reperfusion injury (IRI),
limiting the use of extended criteria donors in liver transplantation (LT). Machine perfusion …
limiting the use of extended criteria donors in liver transplantation (LT). Machine perfusion …
The influence of static portal pressure on liver biophysical properties
Y Safraou, K Krehl, T Meyer, S Mehrgan, JEL Jordan… - Acta Biomaterialia, 2023 - Elsevier
The liver is a highly vascularized organ where fluid properties, including vascular pressure,
vessel integrity and fluid viscosity, play a critical role in gross mechanical properties. To …
vessel integrity and fluid viscosity, play a critical role in gross mechanical properties. To …
Interleukin‐10 and Transforming Growth Factor‐β Cytokines Decrease Immune Activation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
KN Carlson, J Pavan‐Guimaraes… - Liver …, 2021 - Wiley Online Library
Normothermic ex vivo liver perfusion (NEVLP) is a novel system for organ preservation that
may improve over static cold storage clinically and offers the chance for graft modification …
may improve over static cold storage clinically and offers the chance for graft modification …
[HTML][HTML] Continuous Renal Replacement Therapy During Long-term Normothermic Machine Perfusion of Human Donor Livers for up to 7 D
B Lascaris, RF Hoffmann, MWN Nijsten… - Transplantation …, 2024 - journals.lww.com
Background. Normothermic machine perfusion (NMP) is used to preserve and test donor
livers before transplantation. During NMP, the liver is metabolically active and produces …
livers before transplantation. During NMP, the liver is metabolically active and produces …
Hemofiltration improves blood perfusate conditions leading to improved ex situ heart perfusion
SEK genaamd Dengler, M Mishra, MT Vervoorn… - ASAIO …, 2024 - journals.lww.com
The aim was to optimize the perfusate composition by including a hemofiltrator to the
PhysioHeartplatform for ex situ heart perfusion of porcine slaughterhouse hearts. Fourteen …
PhysioHeartplatform for ex situ heart perfusion of porcine slaughterhouse hearts. Fourteen …
Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome
NN Roschke, KH Hillebrandt, D Polenz, O Klein… - Plos one, 2024 - journals.plos.org
Background Considering the expected increase in the elderly population and the growing
emphasis on aging-related biomedical research, the demand for aged laboratory animals …
emphasis on aging-related biomedical research, the demand for aged laboratory animals …
The role of antifreeze glycoprotein (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) as ice modulators during partial freezing of rat livers
SN Tessier, O Haque, CA Pendexter, SEJ Cronin… - Frontiers in …, 2022 - frontiersin.org
Introduction: The current liver organ shortage has pushed the field of transplantation to
develop new methods to prolong the preservation time of livers from the current clinical …
develop new methods to prolong the preservation time of livers from the current clinical …
Normothermic Ex Vivo Liver Machine Perfusion in Mouse
H Chen, O Dirsch, M Albadry, PH Ana… - JoVE (Journal of …, 2023 - jove.com
This protocol presents an optimized erythrocytes-free NEVLP system using mouse livers. Ex
vivo preservation of mouse livers was achieved by employing modified cannulas and …
vivo preservation of mouse livers was achieved by employing modified cannulas and …
The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion
In transplantation, livers are transported to recipients using static cold storage (SCS),
whereby livers are exposed to cold ischemic injury that contribute to post-transplant risk …
whereby livers are exposed to cold ischemic injury that contribute to post-transplant risk …