Progress in the mechanism and targeted drug therapy for COPD
C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
Skeletal muscle inflammation and insulin resistance in obesity
H Wu, CM Ballantyne - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …
[HTML][HTML] Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis
Background Blood pressure lowering is an established strategy for preventing microvascular
and macrovascular complications of diabetes, but its role in the prevention of diabetes itself …
and macrovascular complications of diabetes, but its role in the prevention of diabetes itself …
[HTML][HTML] Telmisartan for treatment of Covid-19 patients: An open multicenter randomized clinical trial
M Duarte, F Pelorosso, LN Nicolosi, MV Salgado… - …, 2021 - thelancet.com
Abstract Background Angiotensin receptor blockers (ARBs), such as telmisartan, have been
postulated to treat Covid-19-induced lung inflammation. Methods This is a parallel-group …
postulated to treat Covid-19-induced lung inflammation. Methods This is a parallel-group …
Understanding the renin–angiotensin–aldosterone–SARS-CoV axis: a comprehensive review
Importance Coronavirus disease 2019 (COVID-19), the disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic …
Inflammatory targets in diabetic nephropathy
J Donate-Correa, D Luis-Rodríguez… - Journal of Clinical …, 2020 - mdpi.com
One of the most frequent complications in patients with diabetes mellitus is diabetic
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress
Hypertension affects one-third of the world's population, leading to cardiac dysfunction that
is modulated by resident and recruited immune cells. Cardiomyocyte growth and increased …
is modulated by resident and recruited immune cells. Cardiomyocyte growth and increased …
Systemic manifestations and comorbidities of COPD
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …
complex disease involving more than airflow obstruction. Airflow obstruction has profound …
Abundant pleiotropy in human complex diseases and traits
S Sivakumaran, F Agakov, E Theodoratou… - The American Journal of …, 2011 - cell.com
We present a systematic review of pleiotropy among SNPs and genes reported to show
genome-wide association with common complex diseases and traits. We find abundant …
genome-wide association with common complex diseases and traits. We find abundant …
[HTML][HTML] Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension
A Chrysanthopoulou, E Gkaliagkousi, A Lazaridis… - JCI insight, 2021 - ncbi.nlm.nih.gov
Innate immunity and chronic inflammation are involved in atherosclerosis and
atherothrombosis, leading to target organ damage in essential hypertension (EH). However …
atherothrombosis, leading to target organ damage in essential hypertension (EH). However …