Introduction The pharmaceutical industry is gradually changing batch-wise manufacturing
processes to continuous manufacturing processes, due to the advantages it has to offer. The …

Extended release formulations play a crucial role in the pharmaceutical industry by
maintaining steady plasma levels, reducing side effects, and improving therapeutic …

In this study, quantitative relationships were established between blend properties, process
settings and blending responses via multivariate data-analysis. Four divergent binary blends …

This study determined the feasibility of long-term continuous powder feeding and its effect
on the overall process performance. Additionally, quantitative relationships were established …

Powder feeding is of critical importance for continuous manufacturing (CM) since next to in-
process segregation it is the phenomenon primarily responsible for fluctuations in content …

In this study, an empirical predictive model was developed based on the quantitative
relationships between blend properties, critical quality attributes (CQA) and critical process …

The current paper shows how excipient properties impact the process parameters and the
final tablet properties in a fully integrated continuous direct compression line. Blend …

In continuous powder handling processes, precise and consistent feeding is crucial for
ensuring the quality of the final product. The intermixing effect caused by agitators, which …

This work presents a novel approach to select gravimetric dosing configurations for
continuous unit operations in pharmaceutical processing. It optimizes material, time, and …

The shift from batch manufacturing towards continuous manufacturing for the production of
oral solid dosages requires the development and implementation of process models and …