Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor
genotype variations among tumors within different patients are known as interpatient …

Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Abstract 'Every Hour Hurts, The Last One Kills'. That is an old saying about getting old. Every
day, thousands of DNA damaging events take place in each cell of our body, but efficient …

Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …

Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …

Aberrant DNA methylation is a common phenomenon in human cancer. The aims of this
study were to investigate the methylation profiles of non-small cell lung cancer (NSCLC) in …

DNA damage response, DNA repair and genomic instability have been under study for their
role in tumor initiation and progression for many years now. More recently, next-generation …

Urinary bladder cancer is the fifth most common cancer in the Western world. Increasing
evidence has shown that DNA methylation in bladder cancer is expansive and is implicated …

Purpose: Epigenetic alterations are common and can now be addressed in a parallel
fashion. We investigated the methylation in bladder cancer with respect to location in …

In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an
important priority for assigning optimal treatment for each individual with suspected illness …