Allogeneic hematopoietic cell transplantation (allo-HCT) is an essential therapeutic modality
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …

Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently
in B‐cell maturation and function. In particular, B‐cell activating factor belonging to the TNF …

Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell
transplantation with few effective options available after failure of corticosteroids. B and T …

Abstract Myeloid differentiation factor 88 (MYD88) L265P somatic mutation is highly
prevalent in Waldenström macroglobulinemia (WM) and supports malignant growth through …

Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the
primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on …

The survival of transitional and mature B cells requires both the B cell antigen receptor
(BCR) and BLyS receptor 3 (BR3), which suggests that these receptors send signals that are …

One remarkable feature of the immune system is its capacity to maintain constant numbers
of resting immune cells despite the complex nature of signals needed throughout …

NF‐κB proteins were identified in the search for mechanisms that regulate B‐lymphocyte‐
specific transcription of immunoglobulin κ light chain genes. Twenty‐five years later, though …

Bruton tyrosine kinase (BTK) is an important signaling hub that activates the B-cell receptor
(BCR) signaling cascade. BCR activation can contribute to the growth and survival of B-cell …

Bruton's tyrosine kinase (BTK) is an intracellular signaling molecule first identified as the
molecule affected in X-linked agammaglobulinemia (XLA) patients, who almost completely …