Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the …

This review summarizes current advances in the role of transcriptional stochasticity in HIV-1
latency, which were possible in a large part due to the development of single-cell …

Complete eradication of HIV-1 infection is impeded by the existence of cells that harbor
chromosomally integrated but transcriptionally inactive provirus. These cells can persist for …

While gene expression noise has been shown to drive dramatic phenotypic variations, the
molecular basis for this variability in mammalian systems is not well understood. Gene …

Here, we review genomic target site selection during retroviral integration as a multistep
process in which specific biases are introduced at each level. The first asymmetries are …

Noisy gene expression generates diverse phenotypes, but little is known about mechanisms
that modulate noise. Combining experiments and modeling, we studied how tumor necrosis …

It is unclear how the activation of HIV-1 transcription affects chromatin structure. We
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …

Activation of gene expression in response to environmental cues results in substantial
phenotypic heterogeneity between cells that can impact a wide range of outcomes including …

Background Chemokine CXCL8 is an important neutrophil chemoattractant implicated in
various neurodegenerative disorders. Cytokine/chemokine imbalance, with an increase in …

The transcription factor nuclear factor (NF)-κB promotes inflammatory and stress-responsive
gene transcription across a range of cell types in response to the cytokine tumor necrosis …