Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …

Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

The field of psychoneuroimmunology (PNI) has grown substantially in both relevance and
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …

The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Abstract Machine learning is increasingly used to discover diagnostic and prognostic
biomarkers from high-dimensional molecular data. However, a variety of factors related to …

Over the past 30 years, the field of cardioimmunology has moved from being dismissed as a
field that was chasing an epiphenomenon of little biological consequence to a scientific …

Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …

The lack of comprehensive diagnostics and consensus analytical models for evaluating the
status of a patient's immune system has hindered a wider adoption of immunoprofiling for …

The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory
infections worldwide. Insightful data obtained in the last years have shed light on the …

Substance use disorder (SUD) is a type of addictive encephalopathy resulting from drug
abuse, which leads to abnormal cerebral alterations indicating neurotoxicity that is …