Molecular tweezers represent the first class of artificial receptor molecules that have made
the way from a supramolecular host to a drug candidate with promising results in animal …

Targeted overexpression of angiotensin-converting enzyme (ACE), an amyloid-β protein
degrading enzyme, to brain resident microglia and peripheral myelomonocytes (ACE 10 …

Recent work on α-synuclein has shown that aggregation is controlled kinetically by the rate
of reconfiguration of the unstructured chain, such that the faster the reconfiguration, the …

Aberrant accumulation and self-assembly of α-synuclein are tightly linked to several
neurodegenerative diseases called synucleinopathies, including idiopathic Parkinson's …

Different tauopathies are characterized by the isoform‐specific composition of the
aggregates found in the brain and by structurally distinct tau strains. Although tau oligomers …

Multiple system atrophy (MSA) is a fatal, adult-onset neurodegenerative disorder that has no
cure and very limited treatment options. MSA is characterized by deposition of fibrillar α …

In type-2 diabetes (T2D), islet amyloid polypeptide (IAPP) self-associates into toxic
assemblies causing islet β-cell death. Therefore, preventing IAPP toxicity is a promising …

Photo-induced cross-linking of unmodified proteins (PICUP) has been used in the past to
study size distributions of protein assemblies. PICUP may, for example, overcome the …

One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the
initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The …

Soluble amyloid-β (Aβ) oligomers have become a focal point in the study of Alzheimer's
disease due to their ability to elicit cytotoxicity. A number of recent studies have concentrated …