In 1999, the World Health Organization (WHO) estimated that one-third of the world's
population had latent tuberculosis infection (LTBI), which was recently updated to one …

Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the
basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) …

Tuberculosis is a public health problem worldwide, including in the United States—
particularly among immunocompromised patients and other high-risk groups. Tuberculosis …

Identification and treatment of latent tuberculosis infection (LTBI) can substantially reduce
the risk of developing active disease. However, there is no diagnostic gold standard for LTBI …

Abstract Exposure to Mycobacterium tuberculosis (Mtb) results in heterogeneous clinical
outcomes including primary progressive tuberculosis and latent Mtb infection (LTBI). Mtb …

The risk of progression from exposure to the tuberculosis bacilli to the development of active
disease is a two‐stage process governed by both exogenous and endogenous risk factors …

Tuberculous meningitis causes substantial mortality and morbidity in children and adults.
More research is urgently needed to better understand the pathogenesis of disease and to …

The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …