Summary In 2010, modified RECIST (mRECIST) criteria were proposed as a way of
adapting the RECIST criteria to the particularities of hepatocellular carcinoma (HCC). We …

On 7 June 2021, aducanumab was granted accelerated approval for the treatment of
Alzheimer disease (AD) by the FDA on the basis of amyloid-lowering effects considered …

Importance The US Food and Drug Administration's (FDA's) accelerated approval pathway
allows investigational cancer drugs to be approved by demonstrating a beneficial effect on a …

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide.
Around half of patients with HCC will receive systemic therapies during their life span. The …

PURPOSE Earlier detection of cancer recurrence using circulating tumor DNA (ctDNA) to
detect molecular residual disease (MRD) has the potential to dramatically affect cancer …

Background Millions of people worldwide suffer from hepatitis C, which can lead to severe
liver disease, liver cancer, and death. Direct‐acting antivirals (DAAs), eg sofosbuvir, are …

Importance The long-term safety of laparoscopic distal gastrectomy for locally advanced
gastric cancer (AGC) remains uncertain given the lack of 5-year follow-up results. Objective …

Objective: To perform an individual participant data meta-analysis using randomized trials
and propensity-score matched (PSM) studies which compared laparoscopic versus open …

Electronic health records (EHRs) are digitally saved health records that provide information
about a person's health. EHRs are generally shared among healthcare stakeholders, and …

PURPOSE Large, generalizable real-world data can enhance traditional clinical trial results.
The current study evaluates reliability, clinical relevance, and large-scale feasibility for a …