[HTML][HTML] Targeting glucose metabolism to overcome resistance to anticancer chemotherapy in breast cancer

E Varghese, SM Samuel, A Líšková, M Samec… - Cancers, 2020 - mdpi.com
Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …

[HTML][HTML] Glucose metabolism and glucose transporters in breast cancer

E Shin, JS Koo - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

[HTML][HTML] Metabolic-pathway-based subtyping of triple-negative breast cancer reveals potential therapeutic targets

Y Gong, P Ji, YS Yang, S Xie, TJ Yu, Y Xiao, ML Jin… - Cell metabolism, 2021 - cell.com
Triple-negative breast cancer (TNBC) remains an unmet medical challenge. We investigated
metabolic dysregulation in TNBCs by using our multi-omics database (n= 465, the largest to …

[HTML][HTML] Metabolic reprogramming in breast cancer and its therapeutic implications

N Gandhi, GM Das - Cells, 2019 - mdpi.com
Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

[HTML][HTML] Metabolic plasticity in chemotherapy resistance

MA Desbats, I Giacomini, T Prayer-Galetti… - Frontiers in …, 2020 - frontiersin.org
Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

[HTML][HTML] Microbiome—microbial metabolome—cancer cell interactions in breast cancer—familiar, but unexplored

E Mikó, T Kovács, É Sebő, J Tóth, T Csonka, G Ujlaki… - Cells, 2019 - mdpi.com
Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant
composition of the microbiome, characterizes breast cancer. In this review we discuss the …

Why all the fuss about oxidative phosphorylation (OXPHOS)?

Y Xu, D Xue, A Bankhead III… - Journal of medicinal …, 2020 - ACS Publications
Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive.
Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells …

[HTML][HTML] Metabolic crosstalk in the breast cancer microenvironment

AS Dias, CR Almeida, LA Helguero, IF Duarte - European Journal of …, 2019 - Elsevier
During tumorigenesis, breast tumour cells undergo metabolic reprogramming, which
generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and …

The balance between breast cancer and the immune system: Challenges for prognosis and clinical benefit from immunotherapies

CN Baxevanis, SP Fortis, SA Perez - Seminars in cancer biology, 2021 - Elsevier
Cancer evolution is a complex process influenced by genetic factors and extracellular stimuli
that trigger signaling pathways to coordinate the continuous and dynamic interaction …

Breast cancer, screening and diagnostic tools: All you need to know

D Barba, A León-Sosa, P Lugo, D Suquillo… - Critical reviews in …, 2021 - Elsevier
Breast cancer is one of the most frequent malignancies among women worldwide. Methods
for screening and diagnosis allow health care professionals to provide personalized …