THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

Appetite is regulated by a complex system of central and peripheral signals which interact in
order to modulate the individual response to nutrient ingestion. Peripheral regulation …

Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health
concern that continues to grow in relevance as the population ages. Certain conditions have …

There is a physiological decline in food intake with aging. The reasons for the decline in
food intake are multifactorial and involve both peripheral and central mechanisms. Altered …

Progressive wasting is common in many types of cancer and is one of the most important
factors leading to early death in cancer patients. Weight loss is a potent stimulus to food …

Weight loss in elderly patients is a common clinical problem. Wasting and cachexia are
associated with severe physiologic, psychologic, and immunologic consequences …

Ciliary Neurotrophic Factor (CNTF) was first characterized as a trophic factor for motor
neurons in the ciliary ganglion and spinal cord, leading to its evaluation in humans suffering …

Appetite is governed by peripheral hormones and central neurotransmitters that act on the
arcuate nucleus of the hypothalamus and nucleus tactus solitarius of the brainstem. Cancer …

ContextObese individuals tend to resist the weight-regulating effects of exogenously
administered leptin. A genetically engineered recombinant human variant ciliary …

Reproductive function declines at both extremes of human energy balance. The relationship
between obesity and reproductive function is complex and incompletely understood. The …