Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …

Adipose-derived stem cells (ASCs) have been increasingly used as a versatile source of
mesenchymal stem cells (MSCs) for diverse clinical investigations. However, their …

Aging is reflected by highly reproducible DNA methylation (DNAm) changes that open new
perspectives for estimation of chronological age in legal medicine. DNA can be harvested …

Despite the uniform selection criteria for the isolation of human mesenchymal stem cells
(MSCs), considerable heterogeneity exists which reflects the distinct tissue origins and …

Abstract Background Mesenchymal stem cells (MSCs) are attracting increasing interest for
cell-based therapies, making use of both their immuno-modulating and regenerative …

Almost from all organs, both mesenchymal stromal cells and fibroblasts can be isolated.
Mesenchymal stromal cells (MSCs) are the most preferred cellular therapeutic agents with …

Clinical-grade mesenchymal stromal cells (MSCs) can be expanded from bone marrow and
adipose tissue to treat inflammatory diseases and degenerative disorders. However, the …

Culture medium of mesenchymal stromal cells (MSCs) is usually supplemented with either
human platelet lysate (HPL) or fetal calf serum (FCS). Many studies have demonstrated that …

Replicative senescence has a major impact on function and integrity of cell preparations.
This process is reflected by continuous DNA methylation (DNA m) changes at specific CpG …