Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes
and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells …

Atherosclerosis (AS) is a pathological process involving lipid oxidation, immune system
activation, and endothelial dysfunction. The activated immune system could lead to …

Genetic and epigenetic modifications of genes involved in the key regulatory pathways play
a significant role in the pathophysiology and progression of multifactorial diseases. The …

The past year was an exciting time for clinical lipidology when we learnt more about existing
therapies as well as therapies targeting novel pathways discovered through genetic studies …

Background Most coronary artery disease (CAD) risk loci identified by genome-wide
association studies (GWAS) are located in non-coding regions, hampering the interpretation …

With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …

Cardiovascular disorders (CVDs) are a major global health concern, but their underlying
molecular mechanisms are not fully understood. Recent research highlights the role of long …

Menopause is accompanied with an increased risk of cardiovascular disease. DNA
methylation may have a significant impact on postmenopausal women's development of …

Aim: Methylation of LDLR, PCSK9 and LDLRAP1 CpG sites was assessed in patients with
familial hypercholesterolemia (FH). Methods: DNA methylation of was analyzed by …

The expression of the Proprotein Convertase Subtilisin/Kexin Type 9 gene (PCSK9) is
inextricably related to lipid levels and a risk of atherosclerotic coronary artery disease …