Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity.
The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small …

Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …

Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …

The spatial organization of chromosomes is critical in establishing gene expression
programs. We generated in situ Hi-C maps throughout zebrafish development to gain insight …

Loss of sensory hair cells leads to deafness and balance deficiencies. In contrast to
mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly …

The activation of cochlear progenitor cells is a promising approach for hair cell (HC)
regeneration and hearing recovery. The mechanisms underlying the initiation of proliferation …

Hearing loss is widespread and persistent because mature mammalian auditory hair cells
(HCs) are nonregenerative. In mice, the ability to regenerate HCs from surrounding …

Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost,
leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals …

In vertebrates, mechano-electrical transduction of sound is accomplished by sensory hair
cells. Whereas mammalian hair cells are not replaced when lost, in fish they constantly …