The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …

Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

Defects in the function of cellular organelles such as peroxisomes, lysosomes and
mitochondria are well-known causes of human diseases. Recently, another organelle has …

Abstract The von Hippel–Lindau disease is caused by inactivating germline mutations of the
VHL tumour suppressor gene and is associated with an increased risk of a variety of …

The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of
spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase …

Hypoxia‐inducible factor (HIF) plays an important role in renal tumourigenesis. In the
majority of clear cell RCC (ccRCC), the most frequent and highly vascularized RCC subtype …

Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …

Germline mutations in the novel tumor suppressor gene FLCN are responsible for the
autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that predisposes to …

The von Hippel–Lindau (VHL) tumor suppressor gene is mutated as an early event in almost
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …

Primary cilia have been proposed to participate in the modulation of growth factor signaling
pathways. In this study, we determined that ciliogenesis is suppressed in both pancreatic …