Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric
cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial …

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

The variant curation guidelines published in 2015 by the American College of Medical
Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) provided …

Classical cadherin Ca2+-dependent cell–cell adhesion proteins play key roles in
embryogenesis and in maintaining tissue integrity. Cadherins mediate robust adhesion by …

Background and Aims Hereditary diffuse gastric cancer (HDGC) accounts for 1% of gastric
cancer cases. For patients with a germline CDH1 mutation, risk-reducing gastrectomy is …

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer
(LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A …

Gastric cancer is the fifth most common cancer and the third most common cause of cancer
death all over the world. E-cadherin encoded by human CDH1 gene plays important roles in …

E-cadherin plays a major role in cell–cell adhesion and inactivating germline mutations in its
encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside …

E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse
gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an …

Background & Aims Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1)
cause a predisposition to gastric cancer. We evaluated the ability of the internationally …