Mitochondria are key organelles involved in energy production as well as numerous
metabolic processes. There is a growing interest in the role of mitochondrial dysfunction in …

Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing
factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating …

Background Obstructive sleep apnea syndrome (OSAS) is associated to intermittent hypoxia
(IH) and is an aggravating factor of non-alcoholic fatty liver disease (NAFLD). We …

Heavy alcohol consumption causes neuronal cell death and cognitive impairment. Neuronal
cell death induced by ethanol may result from increased production of the sphingolipid …

Environmental stressors like ethanol (EtOH) commonly target mitochondria to influence the
cell's fate. Recent literature supports that chronic EtOH exposure suppresses mitochondrial …

Objective Hepatic glucose metabolism is profoundly perturbed by excessive alcohol intake.
miR-141/200c expression is significantly induced by chronic ethanol feeding. This study …

Nonalcoholic fatty liver disease (NAFLD) is a chronic disease affecting the health of many
people worldwide. Previous studies have shown that dietary calcium supplementation may …

Key points Chronic alcohol consumption causes a spectrum of liver diseases, but the
pathogenic mechanisms driving the onset and progression of disease are not clearly …

The relationship between low‐dose alcohol consumption and lipid metabolism has been
extensively studied during the last few decades. It has been reported that low‐dose alcohol …

Mitochondrial Ca 2+ flux is crucial for the regulation of cell metabolism. Ca 2+ entry to the
mitochondrial matrix is mediated by VDAC1 and MCU with its regulatory molecules. We …