Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem

K Evangelou, PVS Vasileiou… - Physiological …, 2023 - journals.physiology.org
Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

Cancer-associated fibroblasts: an emerging target against esophageal squamous cell carcinoma

L Qiu, J Yue, L Ding, Z Yin, K Zhang, H Zhang - Cancer letters, 2022 - Elsevier
Esophageal squamous cell carcinoma (ESCC) is one of the most common human
malignancies worldwide and is associated with high morbidity and mortality. More than 70 …

[HTML][HTML] The dual role of oxidative-stress-induced autophagy in cellular senescence: Comprehension and therapeutic approaches

P Pantelis, G Theocharous, N Lagopati, D Veroutis… - Antioxidants, 2023 - mdpi.com
The contemporary lifestyle of the last decade has undeniably caused a tremendous increase
in oxidative-stress-inducing environmental sources. This phenomenon is not only connected …

[HTML][HTML] Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer

I Mourkioti, A Angelopoulou, K Belogiannis, N Lagopati… - Cells, 2022 - mdpi.com
Prostate cancer belongs in the class of hormone-dependent cancers, representing a major
cause of cancer incidence in men worldwide. Since upon disease onset almost all prostate …

[HTML][HTML] A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

I Mourkioti, A Polyzou, D Veroutis… - Journal of Experimental …, 2023 - Springer
Background Prostate cancer is a major cause of cancer morbidity and mortality in men
worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage …

[HTML][HTML] Home and away: the role of non-coding RNA in intracellular and intercellular DNA damage response

A Shaw, M Gullerova - Genes, 2021 - mdpi.com
Non-coding RNA (ncRNA) has recently emerged as a vital component of the DNA damage
response (DDR), which was previously believed to be solely regulated by proteins. Many …

Multiple RNA profiling reveal epigenetic toxicity effects of oxidative stress by graphene oxide silver nanoparticles in-vitro

YG Yuan, YX Zhang, SZ Liu, AMMT Reza… - International journal …, 2023 - Taylor & Francis
Introduction The increasing industrial and biomedical utilization of graphene oxide silver
nanoparticles (GO-AgNPs) raises the concern of nanosafety: exposure to the AgNPs or GO …

[HTML][HTML] RNA processing mechanisms contribute to genome organization and stability in B cells

E Miglierina, D Ordanoska, S Le Noir, B Laffleur - Oncogene, 2024 - nature.com
RNA processing includes post-transcriptional mechanisms controlling RNA quality and
quantity to ensure cellular homeostasis. Noncoding (nc) RNAs that are regulated by these …

[HTML][HTML] Toward More Comprehensive Homologous Recombination Deficiency Assays in Ovarian Cancer, Part 1: Technical Considerations

S Quesada, M Fabbro, J Solassol - Cancers, 2022 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) is the most frequent and
lethal form of ovarian cancer and is associated with homologous recombination deficiency …

[HTML][HTML] The role of circular RNAs in DNA damage response and repair

A Papaspyropoulos, O Hazapis, N Lagopati, A Polyzou… - Cancers, 2021 - mdpi.com
Simple Summary The role of non-coding RNA, and particularly of circular RNA, in the DNA
damage response and repair network is underappreciated. Given the vital role of this …