Synaptic degeneration in Alzheimer disease

M Tzioras, RI McGeachan, CS Durrant… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

JL Silverman, A Thurm, SB Ethridge… - Genes, brain and …, 2022 - Wiley Online Library
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and
intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence‐based …

Planning experiments: Updated guidance on experimental design and analysis and their reporting III

MJ Curtis, SPH Alexander, G Cirino… - British Journal of …, 2022 - Wiley Online Library
Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article
before undertaking a study. This editorial provides guidance for the design of experiments …

[HTML][HTML] Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies

CC Serdar, M Cihan, D Yücel, MA Serdar - Biochemia medica, 2021 - hrcak.srce.hr
Sažetak Calculating the sample size in scientific studies is one of the critical issues as
regards the scientific contribution of the study. The sample size critically affects the …

[HTML][HTML] ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020

E Lilley, SC Stanford, DE Kendall… - British journal of …, 2020 - ncbi.nlm.nih.gov
1. BACKGROUND The BJP has been and remains an active advocate of the ARRIVE
(Animal Research: Reporting of in vivo Experiments) guidelines (Kilkenny, Browne, Cuthill …

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

N Percie du Sert, V Hurst, A Ahluwalia… - Journal of Cerebral …, 2020 - journals.sagepub.com
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

AD Gruber, TC Firsching, J Trimpert… - Veterinary …, 2022 - journals.sagepub.com
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse

MR Lowerison, NVC Sekaran, W Zhang, Z Dong… - Scientific reports, 2022 - nature.com
Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …

The skin microbiome: current landscape and future opportunities

P Smythe, HN Wilkinson - International journal of molecular sciences, 2023 - mdpi.com
Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour

JK Knudsen, TY Michaelsen, C Bundgaard-Nielsen… - Scientific reports, 2021 - nature.com
Differences in gut microbiota composition have been observed in patients with major
depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal …