Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …

Congenital hypothyroidism is the most common neonatal metabolic disorder and results in
severe neurodevelopmental impairment and infertility if untreated. Congenital …

The Na+/I− symporter (NIS) is an intrinsic membrane protein that mediates the active
transport of iodide into the thyroid and other tissues, such as salivary glands, gastric …

The purpose of this review is to summarize current knowledge of the etiology of euthyroid
and toxic multinodular goiter (MNG) with respect to the epidemiology, clinical characteristics …

Congenital hypothyroidism due to thyroid dyshormonogenesis is a heterogenic disorder that
may be caused by mutations in any of the known steps in the thyroid hormone biosynthesis …

Maintaining the redox balance between generation and elimination of reactive oxygen
species (ROS) is critical for health. Disturbances such as continuously elevated ROS levels …

Thyroid hormone biosynthesis, storage, and secretion require a series of highly regulated
steps. Iodide, the rate-limiting substrate for thyroid hormone synthesis, is actively transported …

Congenital hypothyroidism is a common preventable cause of mental retardation. The
overall incidence is approximately 1: 4000; females are affected about twice as often as …

The Na+/I− symporter (NIS), a 618-amino acid membrane glycoprotein that catalyzes the
active accumulation of I− into thyroid cells, was identified and characterized at the molecular …

Abstract The Na+/I− symporter (NIS) present in the membranes of thyroid cells is responsible
for the capacity of the thyroid to concentrate iodide. This allows treatment of thyroid cancers …