Mast cells are so widely recognized as critical effector cells in allergic disorders and other
immunoglobulin E–associated acquired immune responses that it can be difficult to think of …

The production of hematopoietic cells is under the tight control of a group of hematopoietic
cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic …

Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

Innate immune responses are important in combating various microbes during the early
phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B …

T cell–derived cytokines are important in the development of an effective immune response,
but when dysregulated they can promote disease. Here we identify a four-helix bundle …

Hematopoietic stem and progenitor cells (HSPCs) maintain the adult blood system, and their
dysregulation causes a multitude of diseases. However, the differentiation journeys toward …

Examination of f/kl receptor tyrosine kinase mRNA expression by in situ hybridization
analysis revealed specific association with endothelial cells at all stages of mouse …

In mammals, meiosis is initiated at different time points in males and females, but the
mechanism underlying this difference is unknown. Female germ cells begin meiosis during …

Paramutation is a heritable epigenetic modification induced in plants by cross-talk between
allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of …

Expression of HPV16 early region genes in basal keratinocytes of transgenic mice elicits a
multistage pathway to squamous carcinoma. We report that infiltration by mast cells and …