Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Pantothenic acid, a precursor of coenzyme A (CoA), is essential for the growth of pathogenic
microorganisms. Since the structure of pantothenic acid was determined, many analogues of …

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …

Plasmodium and dengue virus, the causative agents of the two most devastating vector-
borne diseases, malaria and dengue, are transmitted by the two most important mosquito …

The antiplasmodial activity of a series of spirotetrahydro β-carbolines is described. Racemic
spiroazepineindole (1) was identified from a phenotypic screen on wild type Plasmodium …

The growing resistance to current first-line antimalarial drugs represents a major health
challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient …

Several new fluorescence malaria in vitro drug susceptibility microtiter plate assays that
detect the presence of malarial DNA in infected erythrocytes have recently been reported, in …

Background Malaria continues to be a devastating parasitic disease that causes the death of
2 million individuals annually. The increase in multi-drug resistance together with the …

Calcium-dependent protein kinases play a crucial role in intracellular calcium signaling in
plants, some algae and protozoa. In Plasmodium falciparum, calcium-dependent protein …

Mutations in the Plasmodium falciparum Kelch 13 (PfK13) protein are associated with
artemisinin resistance. PfK13 is essential for asexual erythrocytic development, but its …