The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …

The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …

Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …

Calcium balance is essential for a multitude of physiological processes, ranging from cell
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …

The nervous system plays a central role in regulating the stem cell niche in many organs,
and thereby pivotally modulates development, homeostasis, and plasticity. A similarly …

Acetylcholine is a transmitter in preganglionic autonomic and postganglionic
parasympathetic nerves and a non-neuronal paracrine mediator in the alimentary tract …

Simple Summary Recently, cancer research has described the presence of the cholinergic
machinery, specifically muscarinic receptors, in a wide variety of cancers due to their …

An improved understanding of the pathways and mechanisms regulating gastric acid
secretion should lead to the development of novel therapies to prevent and treat acid-peptic …