The case for a renewed focus on Nature in drug discovery is reviewed; not in terms of
natural product screening, but how and why biomimetic molecules, especially those …

Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …

Nucleosides have important therapeutic applications that include antiviral activities against
COVID viruses. It is a common strategy to convert one or multiple of the hydroxyl (OH) units …

As a crucial factor of their therapeutic efficacy, the currently marketed mRNA vaccines
feature uniform substitution of uridine (U) by the corresponding C-nucleoside, pseudouridine …

Highlights•Newly discovered enzymes possessing C-nucleoside synthase activity for
biocatalysis.•Multistep cascade reactions involving up to nine enzymes.•One-pot synthesis …

Cytidine deaminases (CDAs) catalyze the hydrolytic deamination of cytidine and 2′-
deoxycytidine to uridine and 2′-deoxyuridine. Here, we report that prokaryotic homo …

Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), has wrought havoc on the world economy and …

Enzymes continue to gain recognition as valuable tools in synthetic chemistry as they
enable transformations, which elude conventional organochemical approaches. As such …

Nucleoside phosphorylases have progressed from an enzymatic curiosity to a viable
synthetic tool. However, despite the recent advances in nucleoside phosphorylase …

Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …