Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …

Maintaining and modulating mechanical anisotropy is essential for biological processes.
However, how this is achieved at the microscopic scale in living soft matter is not always …

Genomic information must be faithfully transmitted into two daughter cells during mitosis. To
ensure the transmission process, interphase chromatin is further condensed into mitotic …

The compaction of chromatin into mitotic chromosomes is essential for faithful transmission
of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated …

Chromatin organization plays a critical role in cellular function by regulating access to
genetic information. However, understanding chromatin folding is challenging due to its …

DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven
by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids …

Chromosome compaction is a key feature of mitosis and critical for accurate chromosome
segregation. However, a precise quantitative analysis of chromosome geometry during …

Biomolecular condensates are cellular compartments that concentrate biomolecules without
an encapsulating membrane. In recent years, significant advances have been made in the …

How chromatin enzymes work in condensed chromatin and how they maintain diffusional
mobility inside remains unexplored. Here we investigated these challenges using the …