The learning healthcare system uses health information technology and the health data
infrastructure to apply scientific evidence at the point of clinical care while simultaneously …

Introduction The digitalization of medicine has led to a considerable growth of
heterogeneous health datasets, which could improve healthcare research if integrated into …

Calls are increasing for American health care to be organized as a learning health care
system, defined by the Institute of Medicine as a health care system “in which knowledge …

The practice of offering payment to individuals in exchange for their participation in clinical
research is widespread and longstanding. Nevertheless, such payment remains the source …

The rise of quality improvement research and comparative effectiveness research in health
care settings constitutes progress toward the goal of what the Institute of Medicine has called …

Antisense oligonucleotide (ASO) therapies present a promising disease-modifying treatment
approach for rare neurological diseases (RNDs). However, the current focus is on “more …

The authors argue that informed consent is ethically necessary in pragmatic trials that
randomly assign individual patients to treatments, even when treatment options are within …

Growing interest in embedded research approaches—where research is incorporated into
clinical care—has spurred numerous studies to generate knowledge relevant to the real …

Big Data promises to heal many of the complex problems in healthcare. Departing from
conventional ways of thinking about what constitutes relevant health data and how to …

Importance With the increase in trials assessing comparative effectiveness of approved
products and alternative care strategies, guidance is needed to ensure ethical oversight is fit …