[HTML][HTML] Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

X Wei, Y Chen, X Jiang, M Peng, Y Liu, Y Mo, D Ren… - Molecular cancer, 2021 - Springer
Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

H Wang, X Cheng, J Tian, Y Xiao, T Tian, F Xu… - Pharmacology & …, 2020 - Elsevier
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Salvia miltiorrhiza: a potential red light to the development of cardiovascular diseases

L Wang, R Ma, C Liu, H Liu, R Zhu… - Current …, 2017 - ingentaconnect.com
Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat
cardiovascular diseases (CVD) in China and other Asia countries. Here, we summarize …

BMP signaling in vascular biology and dysfunction

AG de Vinuesa, S Abdelilah-Seyfried, P Knaus… - Cytokine & growth factor …, 2016 - Elsevier
The vascular system is critical for developmental growth, tissue homeostasis and repair but
also for tumor development. Bone morphogenetic protein (BMP) signaling has recently …

Hypoxia‐Induced FUS–circTBC1D14 Stress Granules Promote Autophagy in TNBC

Y Liu, Y Liu, Y He, N Zhang, S Zhang, Y Li… - Advanced …, 2023 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is
suggested to be associated with hypoxia. This study is the first to identify a novel circular …

TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells

I Azimi, MJG Milevskiy, E Kaemmerer… - Journal of cell …, 2017 - journals.biologists.com
Hypoxia is a feature of the tumour microenvironment that promotes invasiveness, resistance
to chemotherapeutics and cell survival. Our studies identify the transient receptor potential …

[HTML][HTML] Targeting hypoxia inducible factors-1α as a novel therapy in fibrosis

A Xiong, Y Liu - Frontiers in pharmacology, 2017 - frontiersin.org
Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread
vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF …

Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis

J Yang, H Ueharu, Y Mishina - Bone, 2020 - Elsevier
Energy metabolism is the process of generating energy (ie ATP) from nutrients. This process
is indispensable for cell homeostasis maintenance and responses to varying conditions …

[HTML][HTML] Oxygen homeostasis and cardiovascular disease: A role for HIF?

X Li, Q Zhang, MI Nasser, L Xu, X Zhang, P Zhu… - Biomedicine & …, 2020 - Elsevier
Hypoxia, the decline of tissue oxygen stress, plays a role in mediating cellular processes.
Cardiovascular disease, relatively widespread with increased mortality, is closely correlated …

Effects of curcumin on hypoxia-inducible factor as a new therapeutic target

A Bahrami, SL Atkin, M Majeed, A Sahebkar - Pharmacological research, 2018 - Elsevier
Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two
subunits, the HIF-1α and HIF-1β (ARNT). Under hypoxic conditions, HIF-1 is an adaptive …