Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat
cardiovascular diseases (CVD) in China and other Asia countries. Here, we summarize …

The vascular system is critical for developmental growth, tissue homeostasis and repair but
also for tumor development. Bone morphogenetic protein (BMP) signaling has recently …

Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is
suggested to be associated with hypoxia. This study is the first to identify a novel circular …

Hypoxia is a feature of the tumour microenvironment that promotes invasiveness, resistance
to chemotherapeutics and cell survival. Our studies identify the transient receptor potential …

Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread
vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF …

Energy metabolism is the process of generating energy (ie ATP) from nutrients. This process
is indispensable for cell homeostasis maintenance and responses to varying conditions …

Hypoxia, the decline of tissue oxygen stress, plays a role in mediating cellular processes.
Cardiovascular disease, relatively widespread with increased mortality, is closely correlated …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two
subunits, the HIF-1α and HIF-1β (ARNT). Under hypoxic conditions, HIF-1 is an adaptive …