Overview and limitations of database in global traditional medicines: A narrative review

X Li, J Zhang, X Shen, Y Zhang, D Guo - Acta Pharmacologica Sinica, 2024 - nature.com
The study of traditional medicine has garnered significant interest, resulting in various
research areas including chemical composition analysis, pharmacological research, clinical …

Integration of Omics Data and Network Models to Unveil Negative Aspects of SARS-CoV-2, from Pathogenic Mechanisms to Drug Repurposing

L Bernardo, A Lomagno, PL Mauri, D Di Silvestre - Biology, 2023 - mdpi.com
Simple Summary SARS-CoV-2 caused the COVID-19 health emergency, affecting millions
of people worldwide. Samples collected from hospitalized or dead patients from the early …

CMAUP database update 2024: extended functional and association information of useful plants for biomedical research

D Hou, H Lin, Y Feng, K Zhou, X Li, Y Yang… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Knowledge of the collective activities of individual plants together with the derived
clinical effects and targeted disease associations is useful for plant-based biomedical …

[HTML][HTML] In Vivo Regulation of Small Molecule Natural Products, Antioxidants, and Nutrients by OAT1 and OAT3

K Falah, P Zhang, AK Nigam, K Maity, G Chang… - Nutrients, 2024 - mdpi.com
The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) are drug
transporters that are expressed in the kidney, with well-established roles in the in vivo …

COCONUT 2.0: a comprehensive overhaul and curation of the collection of open natural products database

V Chandrasekhar, K Rajan, SRS Kanakam… - Nucleic Acids …, 2024 - academic.oup.com
Abstract The COCONUT (COlleCtion of Open Natural prodUcTs) database was launched in
2021 as an aggregation of openly available natural product datasets and has been one of …

SIDERITE: Unveiling hidden siderophore diversity in the chemical space through digital exploration

R He, S Gu, J Xu, X Li, H Chen, Z Shao, F Wang… - iMeta, 2024 - Wiley Online Library
Siderophore is a diverse family of secondary metabolites that exhibit high affinities for
binding and chelating iron, one of the essential elements for cellular processes, including …

Polymethoxylated flavonoids in citrus fruits: absorption, metabolism, and anticancer mechanisms against breast cancer

Y Wang, Y Mou, S Lu, Y Xia, B Cheng - PeerJ, 2024 - peerj.com
Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that
have shown multifunctional biological activities and potential anticancer effects against …

A comprehensive computational study to explore promising natural bioactive compounds targeting glycosyltransferase MurG in Escherichia coli for potential drug …

A Shtaiwi, SU Khan, M Khedraoui, M Alaraj… - Scientific reports, 2024 - nature.com
Peptidoglycan is a carbohydrate with a cross-linked structure that protects the cytoplasmic
membrane of bacterial cells from damage. The mechanism of peptidoglycan biosynthesis …

[HTML][HTML] Natural Product Databases for Drug Discovery: Features and Applications

T Zeng, J Li, R Wu - Pharmaceutical Science Advances, 2024 - Elsevier
Natural products (NPs) exhibit diverse chemical structures and biological activities that make
them valuable sources for drug discovery. With advancements in computational technology …

Natural Products Dereplication: Databases and Analytical Methods

I Pérez-Victoria - Progress in the Chemistry of Organic Natural Products …, 2024 - Springer
The development of efficient methods for dereplication has been critical in the re-emergence
of the research in natural products as a source of drug leads. Current dereplication …