Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

Glucocorticoids regulate fundamental processes of the human body and control cellular
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid
arthritis. The study of synovial tissue has advanced considerably throughout the past few …

Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer
immunotherapy. A better understanding of how these iatrogenic diseases compare with …

Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic
rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other …

Dendritic cells (DCs) are the key professional antigen-presenting cells which bridge innate
and adaptive immune responses, inducing the priming and differentiation of naive to effector …

Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by
symmetrical peripheral polyarthritis in the hands and/or feet, leading to long-term disability if …

Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of
autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, multiple sclerosis …

T-cell antigen receptor (TCR) variability enables the cellular immune system to discriminate
between self and non-self. High-throughput TCR sequencing (TCR-seq) involves the use of …