The prognosis for patients with biliary tract cancers (cholangiocarcinoma and gallbladder
cancer) is poor, while the incidence of these cancers is increasing. Most patients are …

FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

Translational research has revolutionized how we develop new treatments for cancer
patients. The change from an organ-centric concept guiding treatment choice towards deep …

The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …

Fibroblast growth factor receptors (FGFRs) play key roles in promoting the proliferation,
differentiation, and migration of cancer cell. Inactivation of FGFRs by tyrosine kinase …

The human fibroblast growth factor family consists of 22 factors and five transmembrane
receptors. Of the 22 factors, eighteen are secreted while four of them function exclusively …

The fibroblast growth factor receptor (FGFR) signaling pathway is aberrantly activated in
approximately 15% to 20% of patients with intrahepatic cholangiocarcinoma. Currently …

Targeted therapy is a groundbreaking innovation for cancer treatment. Among the receptor
tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial …

Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, with an
increasing mortality rate. Aberrant expression of fibroblast growth factor 19–fibroblast growth …

Precision oncology relies on the identification of molecular alterations, responsible for tumor
initiation and growth, which are suitable targets of specific inhibitors. The development of …