Sustainable biosynthesis of 3-hydroxypropionic acid from crude glycerol: Metabolic engineering and process optimization

Y Zhang, J Yun, L Zhou, G Zhang, M Zhao… - Journal of Cleaner …, 2023 - Elsevier
To achieve carbon neutrality and carbon peaking goals, biomanufacturing of high-value
chemicals from sustainable biorefinery has emerged as an attractive alternative to traditional …

Just passing through: Deploying aquaporins in microbial cell factories

LR Jenkins Sánchez, LM Sips… - Biotechnology …, 2024 - Wiley Online Library
As microbial membranes are naturally impermeable to even the smallest biomolecules,
transporter proteins are physiologically essential for normal cell functioning. This makes …

Revealing thermodynamics and kinetics of lipid self-assembly by Markov state model analysis

J Weng, M Yang, W Wang, X Xu… - Journal of the American …, 2020 - ACS Publications
Self-assembly is ubiquitous in the realm of biology and has become an elegant bottom-up
approach to fabricate new materials. Although molecular dynamics (MD) simulations can …

Efficient biosynthesis of 3-hydroxypropionic acid from glucose through multidimensional engineering of Escherichia coli

Y Zhang, J Yun, G Zhang, A Parvez, L Zhou… - Bioresource …, 2023 - Elsevier
Hydroxypropionic acid (3-HP) is a top value-added chemical with multifaceted application in
chemical, material, and food field. However, limited availability of robust strains and elevated …

Advances in biotin biosynthesis and biotechnological production in microorganisms

JR Zhao, SQ Zuo, F Xiao, FZ Guo, LY Chen… - World Journal of …, 2024 - Springer
Biotin, also known as vitamin H or B7, acts as a crucial cofactor in the central metabolism
processes of fatty acids, amino acids, and carbohydrates. Biotin has important applications …

The hitchhiker's guide to the periplasm: Unexpected molecular interactions of polymyxin B1 in E. coli

C Pedebos, IPS Smith, A Boags, S Khalid - Structure, 2021 - cell.com
The periplasm of Gram-negative bacteria is a complex, highly crowded molecular
environment. Little is known about how antibiotics move across the periplasm and the …

[HTML][HTML] Structural assessment of OsNIP2; 1 highlighted critical residues defining solute specificity and functionality of NIP class aquaporins

Y Sharma, V Thakral, G Raturi, KD Dubey… - Journal of Advanced …, 2024 - Elsevier
Introduction Nodulin-26-like intrinsic proteins (NIPs) are integral membrane proteins
belonging to the aquaporin family, that facilitate the transport of neutral solutes across the …

Molecular mechanism of methanol inhibition in CALB-catalyzed alcoholysis: Analyzing molecular dynamics simulations by a Markov state model

HF Carvalho, V Ferrario, J Pleiss - Journal of Chemical Theory …, 2021 - ACS Publications
Lipases are widely used enzymes that catalyze hydrolysis and alcoholysis of fatty acid
esters. At high concentrations of small alcohols such as methanol or ethanol, many lipases …

Molecular Crowding Alters the Interactions of Polymyxin Lipopeptides within the Periplasm of E. coli: Insights from Molecular Dynamics

IPS Smith, C Pedebos, S Khalid - The Journal of Physical …, 2024 - ACS Publications
The cell envelope of Gram-negative bacteria is a crowded tripartite architecture that
separates the cell interior from the external environment. Two membranes encapsulate the …

Impacts of external electric fields on the permeation of glycerol and water molecules through aquaglyceroporin-7: molecular dynamics simulation approach

Z Rahimi, A Lohrasebi - The European Physical Journal E, 2023 - Springer
Abstract The aquaglyceroporin-7 (AQP7) protein channels facilitate the permeation of
glycerol and water molecules through cell membranes by passive diffusion and play a …