Developmental mechanisms underlying the evolution of human cortical circuits

P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

Amplification of human interneuron progenitors promotes brain tumors and neurological defects

OL Eichmüller, NS Corsini, Á Vértesy, I Morassut… - Science, 2022 - science.org
Evolutionary development of the human brain is characterized by the expansion of various
brain regions. Here, we show that developmental processes specific to humans are …

Mouse and human share conserved transcriptional programs for interneuron development

Y Shi, M Wang, D Mi, T Lu, B Wang, H Dong, S Zhong… - Science, 2021 - science.org
INTRODUCTION The cerebral cortex contains two main classes of neurons that derive from
distinct structures in the developing telencephalon. Excitatory neurons originate from …

[HTML][HTML] Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis

CCL Chen, S Deshmukh, S Jessa, D Hadjadj, V Lisi… - Cell, 2020 - cell.com
Summary Histone H3. 3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …

Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease

A Taubes, P Nova, KA Zalocusky, I Kosti, M Bicak… - Nature Aging, 2021 - nature.com
The evident genetic, pathological and clinical heterogeneity of Alzheimer's disease (AD)
poses challenges for traditional drug development. We conducted a computational drug …

Human cerebral organoids—a new tool for clinical neurology research

OL Eichmüller, JA Knoblich - Nature Reviews Neurology, 2022 - nature.com
The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Immature excitatory neurons develop during adolescence in the human amygdala

SF Sorrells, MF Paredes, D Velmeshev… - Nature …, 2019 - nature.com
The human amygdala grows during childhood, and its abnormal development is linked to
mood disorders. The primate amygdala contains a large population of immature neurons in …

Human intermediate progenitor diversity during cortical development

MP Pebworth, J Ross, M Andrews… - Proceedings of the …, 2021 - National Acad Sciences
Studies of the spatiotemporal, transcriptomic, and morphological diversity of radial glia (RG)
have spurred our current models of human corticogenesis. In the developing cortex, neural …

Shared and derived features of cellular diversity in the human cerebral cortex

DJ Miller, A Bhaduri, N Sestan, A Kriegstein - Current opinion in …, 2019 - Elsevier
Highlights•Human cerebral cortex contains 100s of cell types.•Basic cellular organization of
the cortex is conserved but varies across mammals.•Human neural progenitors are highly …