Developmental mechanisms underlying the evolution of human cortical circuits
P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
New insights into the development of the human cerebral cortex
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …
presumed to be responsible for the neuronal computations underlying complex phenomena …
Amplification of human interneuron progenitors promotes brain tumors and neurological defects
OL Eichmüller, NS Corsini, Á Vértesy, I Morassut… - Science, 2022 - science.org
Evolutionary development of the human brain is characterized by the expansion of various
brain regions. Here, we show that developmental processes specific to humans are …
brain regions. Here, we show that developmental processes specific to humans are …
Mouse and human share conserved transcriptional programs for interneuron development
INTRODUCTION The cerebral cortex contains two main classes of neurons that derive from
distinct structures in the developing telencephalon. Excitatory neurons originate from …
distinct structures in the developing telencephalon. Excitatory neurons originate from …
[HTML][HTML] Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis
Summary Histone H3. 3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease
The evident genetic, pathological and clinical heterogeneity of Alzheimer's disease (AD)
poses challenges for traditional drug development. We conducted a computational drug …
poses challenges for traditional drug development. We conducted a computational drug …
Human cerebral organoids—a new tool for clinical neurology research
OL Eichmüller, JA Knoblich - Nature Reviews Neurology, 2022 - nature.com
The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …
patients and from animal models of disease. However, most patient studies do not capture …
Immature excitatory neurons develop during adolescence in the human amygdala
The human amygdala grows during childhood, and its abnormal development is linked to
mood disorders. The primate amygdala contains a large population of immature neurons in …
mood disorders. The primate amygdala contains a large population of immature neurons in …
Human intermediate progenitor diversity during cortical development
Studies of the spatiotemporal, transcriptomic, and morphological diversity of radial glia (RG)
have spurred our current models of human corticogenesis. In the developing cortex, neural …
have spurred our current models of human corticogenesis. In the developing cortex, neural …
Shared and derived features of cellular diversity in the human cerebral cortex
Highlights•Human cerebral cortex contains 100s of cell types.•Basic cellular organization of
the cortex is conserved but varies across mammals.•Human neural progenitors are highly …
the cortex is conserved but varies across mammals.•Human neural progenitors are highly …