As the indispensable second cellular messenger, calcium signaling is involved in the
regulation of almost all physiological processes by activating specific target proteins. The …

The cell division cycle is the generational period of cellular growth and propagation. Cell
cycle progression needs to be highly regulated to preserve genomic fidelity while increasing …

Current methods for comparing single-cell RNA sequencing datasets collected in multiple
conditions focus on discrete regions of the transcriptional state space, such as clusters of …

Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset
disease that often causes death or severe disability. Although genome-wide association …

Inflammation in the bone marrow (BM) microenvironment is a constitutive component of
leukemogenesis in acute myeloid leukemia (AML). Current evidence suggests that both …

Importance Moyamoya disease (MMD), a progressive vasculopathy leading to narrowing
and ultimate occlusion of the intracranial internal carotid arteries, is a cause of childhood …

Abstract Interferon regulatory factor 7 (IRF7) is widely studied in inflammatory models. Its
effects on malignant progression have been documented mainly from the perspective of the …

Simple Summary Cyclin-dependent kinases are involved in the regulation of cancer-
initiating processes like cell cycle progression, transcription, and DNA repair. In …

Reprogramming of cellular identity is fundamentally at odds with replication of the genome:
cell fate reprogramming requires complex multidimensional epigenomic changes, whereas …

The process of cancer initiation and development is regulated via the transcriptional
expression of cells going under genomic and epigenetic changes. Targeting epigenetic …