Annexin A1 as a regulator of immune response in cancer

TG Araújo, STS Mota, HSV Ferreira, MA Ribeiro… - Cells, 2021 - mdpi.com
Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria

C Dahlgren, M Gabl, A Holdfeldt, M Winther… - Biochemical …, 2016 - Elsevier
Proper recruitment and activation of neutrophils to/at sites of infection/inflammation relies
largely on the surface expression of chemoattractant receptors of which a formyl peptide …

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

R Yang, F Mele, L Worley, D Langlais, J Rosain… - Cell, 2020 - cell.com
Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease.
We report a patient with mycobacterial disease due to inherited deficiency of the …

The viral protein corona directs viral pathogenesis and amyloid aggregation

K Ezzat, M Pernemalm, S Pålsson, TC Roberts… - Nature …, 2019 - nature.com
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which
significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses …

The meningeal transcriptional response to traumatic brain injury and aging

AC Bolte, DA Shapiro, AB Dutta, WF Ma, KR Bruch… - Elife, 2023 - elifesciences.org
Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …

The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through the AMPK/PPARα/CPT1b pathway

L Wu, C Liu, DY Chang, R Zhan, M Zhao… - Diabetes, 2021 - Am Diabetes Assoc
Inflammation and abnormal metabolism play important roles in the pathogenesis of diabetic
nephropathy (DN). Annexin A1 (ANXA1) contributes to inflammation resolution and …

Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

V Gerke, FNE Gavins, M Geisow, T Grewal… - Nature …, 2024 - nature.com
Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic
phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+ …

Annexin A1 localization and its relevance to cancer

Z Boudhraa, B Bouchon, C Viallard, M D'Incan… - Clinical …, 2016 - portlandpress.com
Annexin A1 (ANXA1) is a Ca2+-regulated phospholipid-binding protein involved in various
cell processes. ANXA1 was initially widely studied in inflammation resolution, but its …

Dysregulation of TFH-BTRM lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer

JW Cho, S Park, G Kim, H Han, HS Shim, S Shin… - Nature …, 2021 - nature.com
Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor
(EGFR) mutations exhibit an unfavorable response to PD-1 inhibitor through unclear …

An overview on immunogenic cell death in cancer biology and therapy

MC Rodrigues, JAV Morais, R Ganassin, GRT Oliveira… - Pharmaceutics, 2022 - mdpi.com
Immunogenic cell death (ICD) is a modality of regulated cell death that is sufficient to
promote an adaptive immune response against antigens of the dying cell in an …