Hosting the plant cells in vitro: recent trends in bioreactors

MI Georgiev, R Eibl, JJ Zhong - Applied microbiology and Biotechnology, 2013 - Springer
Biotechnological production of high-value metabolites and therapeutic proteins by plant in
vitro systems has been considered as an attractive alternative of classical technologies …

Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells

DL Hacker, D Kiseljak, Y Rajendra, S Thurnheer… - Protein expression and …, 2013 - Elsevier
Transient gene expression (TGE) from mammalian cells is an increasingly important tool for
the rapid production of recombinant proteins for research applications in biochemistry …

Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale

W Klöckner, R Gacem, T Anderlei, N Raven… - Journal of biological …, 2013 - Springer
Background Among disposable bioreactor systems, cylindrical orbitally shaken bioreactors
show important advantages. They provide a well-defined hydrodynamic flow combined with …

[PDF][PDF] Computational fluid dynamics as a modern tool for engineering characterization of bioreactors

S Werner, SC Kaiser, M Kraume… - Pharmaceutical …, 2014 - researchgate.net
Werner, Kaiser, Kraume & Eibl dynamics (CFD) modeling has become a widely accepted
numerical technique for studying local characteristics (eg, liquid velocity, gas holdup and …

[图书][B] Mass production of mesenchymal stem cells—impact of bioreactor design and flow conditions on proliferation and differentiation

V Jossen, R Pörtner, SC Kaiser, M Kraume, D Eibl… - 2014 - books.google.com
Stem cells have enormous potential in health and medical research due to their ability to
differentiate into specialized cells and to self-renew. Applications can be seen in cell-based …

Bioreactor technology for sustainable production of plant cell-derived products

S Werner, RW Maschke, D Eibl… - Bioprocessing of plant …, 2018 - digitalcollection.zhaw.ch
The successful cultivation of plant cell and tissue cultures for the production of valuable
chemical components requires the selection of an appropriate bioreactor. Selection criteria …

CFD modelling of a wave-mixed bioreactor with complex geometry and two degrees of freedom motion

S Seidel, RW Maschke, M Kraume, R Eibl… - Frontiers in Chemical …, 2022 - frontiersin.org
Optimizing bioprocesses requires an in-depth understanding, from a bioengineering
perspective, of the cultivation systems used. A bioengineering characterization is typically …

Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up

C Löffelholz, SC Kaiser, M Kraume, R Eibl… - Disposable bioreactors II, 2014 - Springer
During the past 10 years, single-use bioreactors have been well accepted in modern
biopharmaceutical production processes targeting high-value products. Up to now, such …

Single‐use bioreactors–an overview

V Jossen, R Eibl, D Eibl - Single‐use technology in …, 2019 - Wiley Online Library
This chapter aims to give an overview of instrumented single‐use bioreactor (SUB) types
that are currently available commercially. Based on the milestones in the development of …

Single‐use Technology for the Production of Cellular Agricultural Products: Where are We Today?

C Schirmer, R Eibl, RW Maschke… - Chemie Ingenieur …, 2022 - Wiley Online Library
Single‐use Technology for the Production of Cellular Agricultural Products: Where are We
Today? - Schirmer - 2022 - Chemie Ingenieur Technik - Wiley Online Library Skip to Article …