Antigen arrays for profiling autoantibody repertoires
Autoantibodies are a key component for the diagnosis, prognosis and monitoring of various
diseases. In order to discover novel autoantibody targets, highly multiplexed assays based …
diseases. In order to discover novel autoantibody targets, highly multiplexed assays based …
[HTML][HTML] Why current quantitative serology is not quantitative and how systems immunology could provide solutions
J Prechl - Biologia Futura, 2021 - Springer
Determination of the presence of antibodies against infectious agents, self-antigens,
allogeneic antigens and environmental antigens is the goal of medical serology. Along with …
allogeneic antigens and environmental antigens is the goal of medical serology. Along with …
[HTML][HTML] Novel autoantibody signatures in sera of patients with pancreatic cancer, chronic pancreatitis and autoimmune pancreatitis: a protein microarray profiling …
S Ghassem-Zadeh, K Hufnagel, A Bauer… - International journal of …, 2020 - mdpi.com
Identification of disease-associated autoantibodies is of high importance. Their assessment
could complement current diagnostic modalities and assist the clinical management of …
could complement current diagnostic modalities and assist the clinical management of …
Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation
T Luetkens, S Kobold, Y Cao, M Ristic… - Cancer immunology …, 2014 - Springer
Background Multiple myeloma (MM) is the malignancy with the most frequent expression of
the highly immunogenic cancer–testis antigens (CTA), and we have performed the first …
the highly immunogenic cancer–testis antigens (CTA), and we have performed the first …
[HTML][HTML] Use of autoreactive antibodies in blood of patients with pancreatic intraductal papillary mucinous neoplasms (IPMN) for grade distinction and detection of …
Simple Summary Risk stratification via biomarkers used with imaging could support
predicting high-risk pancreatic intraductal papillary mucinous neoplasms (IPMN) with …
predicting high-risk pancreatic intraductal papillary mucinous neoplasms (IPMN) with …
Protein microarrays for genome‐wide posttranslational modification analysis
Y Merbl, MW Kirschner - Wiley Interdisciplinary Reviews …, 2011 - Wiley Online Library
Protein microarray technology has emerged as a powerful tool for comparing binding
interactions, expression level, substrate specificities, and posttranslational modifications …
interactions, expression level, substrate specificities, and posttranslational modifications …
Progression of lupus-like disease drives the appearance of complement-activating IgG antibodies in MRL/lpr mice
Objectives. Nucleic acids are known to induce complement activation, which results in the
masking and removal of apoptotic cells exposing nuclear components. Dysregulation of …
masking and removal of apoptotic cells exposing nuclear components. Dysregulation of …
[HTML][HTML] Serological and genetic evidence for altered complement system functionality in systemic lupus erythematosus: findings of the GAPAID consortium
Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial
ethiopathogenesis. The complement system is involved in both the early and late stages of …
ethiopathogenesis. The complement system is involved in both the early and late stages of …
[HTML][HTML] Application of fluorescent monocytes for probing immune complexes on antigen microarrays
Microarrayed antigens are used for identifying serum antibodies with given specificities and
for generating binding profiles. Antibodies bind to these arrayed antigens forming immune …
for generating binding profiles. Antibodies bind to these arrayed antigens forming immune …
Characterization of factors influencing on-chip complement activation to optimize parallel measurement of antibody and complement proteins on antigen microarrays
Binding of immunoglobulins and complement fragments to targets of adaptive immune
responses can be monitored using collections of arrayed antigens and is used to generate …
responses can be monitored using collections of arrayed antigens and is used to generate …