Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Lipids in the brain are major components playing structural functions as well as
physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic …

Abstract l-3, 4-Dihydroxyphenylalanine (l-DOPA) remains the most effective symptomatic
treatment of Parkinson's disease (PD). However, long-term administration of l-DOPA is …

Lipids are not only constituents of cellular membranes, but they are also key signaling
mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive …

In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …

Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …

Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …