Highlights•Structural LTP produces opposite effects at synapses on immature versus adult
dendrites.•Local subcellular compartments mediate synaptogenesis at P15 and synapse …

In presynaptic terminals, synaptic vesicles (SVs) are found in a discrete cluster that includes
a reserve pool that is mobilized during synaptic activity. Synapsins serve as a key protein for …

Pre-and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic
mechanisms underlying learning and memory. At layer 5 pyramidal neurons, LTP increases …

The endolysosomal system is present in all cell types. Within these cells, it performs a series
of essential roles, such as trafficking and sorting of membrane cargo, intracellular signaling …

Cyclic adenosine monophosphate (cAMP) is a crucial second messenger involved in both
pre-and postsynaptic plasticity in many neuronal types across species. In the hippocampal …

For decades, the synaptic vesicle cluster has been thought of as a storage space for
synaptic vesicles, whose obvious function is to provide vesicles for the depolarization …

Synaptic plasticity is a cellular model for learning and memory. However, the expression
mechanisms underlying presynaptic forms of plasticity are not well understood. Here, we …

The BAD-BAX-caspase-3 cascade is a canonical apoptosis pathway. Macroautophagy
(“autophagy” hereinafter) is a process by which organelles and aggregated proteins are …

Brain-derived neurotropic factor (BDNF) has been shown to play critical roles in neural
development, plasticity, and neurodegenerative diseases. The main function of BDNF in the …

Fast, high-fidelity neurotransmission and synaptic efficacy requires tightly regulated
coordination of pre-and postsynaptic compartments and alignment of presynaptic release …