Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

MicroRNAs play important roles in cell differentiation by acting as translational inhibitors of
specific target genes. Here we show that human granulocytic differentiation is controlled by …

Non-liganded retinoic acid receptors (RARs) repress transcription of target genes by
recruiting the histone deacetylase complex,, through a class of silencing mediators termed …

This review highlights new findings that have deepened our understanding of the
mechanisms of leukemogenesis, therapy and resistance in acute promyelocytic leukemia …

Low concentrations of As2O3 (≤ 1 μmol/L) induce long-lasting remission in patients with
acute promyelocytic leukemia (APL) without significant myelosuppressive side effects …

Despite its many therapeutic qualities, arsenic trioxide has been more commonly
remembered as Madame Bovary's poison than as an anticancer drug. The ability of arsenic …

Analyzing the pathways by which retinoic acid (RA) induces promyelocytic leukemia/retinoic
acid receptor α (PML/RAR α) catabolism in acute promyelocytic leukemia (APL), we found …

Acute promyelocytic leukaemia (APL), associated with chromosomal translocations
involving the retinoic acid receptor α gene (RARA) and the PML gene, is sensitive to retinoic …

Many different molecular mechanisms have been associated with PML-RARα-dependent
transformation of hematopoietic progenitors. Here, we identified high confidence PML-RARα …