Breast cancer is one of the familiar diseases in women. Incidence and mortality due to
cancer, particularly breast cancer has been increasing for last 50 years, even though there is …

CA 15-3 which detects soluble forms of MUC-1 protein is the most widely used serum
marker in patients with breast cancer. Its main use is for monitoring therapy in patients with …

MUC1 is a large, heavily glycosylated mucin expressed on the apical surfaces of most
simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory …

Recommendations are presented for the routine clinical use of serum and tissue-based
markers in the diagnosis and management of patients with breast cancer. Their low …

Agents able to bind tightly and selectively to disease markers can greatly benefit disease
diagnosis and therapy. Aptamers are functional molecules, usually DNA or RNA …

The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma
and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly …

MUC1 is a large (> 400 kDa), heavily glycosylated transmembrane protein that is aberrantly
expressed on greater than 90% of human breast carcinomas and subsequent metastases …

Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy
cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of …

The majority of cancers arise from malignant epithelial cells. We report the design of
synthetic oligonucleotides (aptamers) that are only internalized by epithelial cancer cells …

Chemotherapy, radiation, and growth inhibitory drugs preferentially eliminate actively
growing cancer cells. Cancer recurrence is currently thought to be due to nondividing cancer …