Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …

Neurodegenerative disorders affect almost 30 million individuals leading to disability and
death. These disorders are characterized by pathological changes in disease-specific areas …

Parkinson's disease is one of the most common neurodegenerative diseases in the elderly.
The motor symptoms occur predominantly due to substantial dopamine depletion, caused by …

Parkinson's disease is a debilitating disorder characterized by a progressive loss of
dopaminergic neurons caused by programmed cell death. The aim of this review is to …

Neurological diseases, which consist of acute injuries and chronic neurodegeneration, are
the leading causes of human death and disability. However, the pathophysiology of these …

Chemobrain refers to a common sequelae experienced by 15–80% of cancer patients
exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been …

P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …

NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS
disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of …