Histone deacetylases (HDACs) are enzymes pursued as drug targets in various cancers and
several non-oncological conditions, such as inflammation and neurodegenerative disorders …

As an underrepresented functional group in bioorganic and medicinal chemistry, the
hydroxylamine unit has historically received little attention from the synthetic community …

Herein, we report visible light and N-heterocyclic carbene (NHC) jointly promoted
multicomponent carbene transfer reactions. Under the optimized reaction conditions, two …

Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family mainly targeting
cytosolic nonhistone substrates, such as α-tubulin, cortactin, and heat shock protein 90 to …

The development of drugs for the treatment of advanced prostate cancer (PCA) remains a
challenging task. In this study we have designed, synthesized and tested twenty-nine novel …

Metastases to the brain remain a significant problem in lung cancer, as treatment by most
small-molecule targeted therapies is severely limited by efflux transporters at the blood …

Hydroxamic acids bearing an (O, O) donor set are well-known metal-chelating compounds
with diverse biological activities including anticancer activity. Since steroid conjugation with …

Bacteria secrete siderophores whose function is to acquire iron. In recent years, the
siderophores of several Chryseobacterium species were shown to promote the health and …

This study aimed to design potent carbonic anhydrase inhibitors (CAIs) based on pyrazole
benzenesulfonamide core. Nine series of substituted pyrazole benzenesulfonamide …

Schistosomiasis is one of the most important neglected tropical diseases. Until an effective
vaccine is registered for use, the cornerstone of schistosomiasis control remains …