Extracellular vesicles (EVs) are cornerstones of intercellular communication with exciting
fundamental, clinical, and more broadly biotechnological applications. However, variability …

Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …

Integrins are heterodimeric receptors comprising α and β subunits. They are expressed on
the cell surface and play key roles in cell adhesion, migration, and growth. Several types of …

Background Procoagulant platelets are a subpopulation of highly activated platelets that
promote coagulation through surface-exposed, negatively charged phospholipids …

Objective It is unclear why activated platelets and platelet‐derived microparticles (MPs)
accumulate in the blood of patients with systemic sclerosis (SSc). This study was undertaken …

Implantable Cardiovascular Therapeutic Devices (CTD), while lifesaving, impart
supraphysiologic shear stress to platelets, resulting in thrombotic and bleeding …

Objective Non-physiological shear stress (NPSS) and thrombin have two distinct
mechanisms for activating platelets. NPSS in mechanically assisted circulation (MAC) …

Background Mechanical circulatory support (MCS) is a mainstay of therapy for advanced
and end-stage heart failure. Accompanied by systemic anticoagulation, contemporary MCS …

Background Left ventricular assist devices (LVADs) have been used as a standard treatment
option for patients with advanced heart failure. However, these devices are prone to adverse …

Abstract Background Microvesicles (MVs) produced by platelets upon activation possess
high procoagulant activity and represent a possible thrombotic risk marker. However, direct …