Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

Cancer is one of the greatest challenges of the modern medicine. Although much effort has
been made in the development of novel cancer therapeutics, it still remains one of the most …

Marine natural products as secondary metabolites are a potential major source of new drugs
for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of …

For the first time a general overview of approaches to the synthesis of natural product
analogues is presented. This reflects a process of evolution of natural product synthesis …

Covering: 2000 up to 2016 Peloruside A, a macrocyclic secondary metabolite from a New
Zealand marine sponge, Mycale hentscheli, has shown potent antiproliferative activity in …

The search for compounds capable of targeting early pathological changes of Alzheimer̀s
disease (AD), such as oxidative stress and neuroinflammation, is an important challenge …

Dess–Martin periodinane (DMP), a commercially available chemical, is frequently utilized as
a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their …

A concise synthesis of the C9–C19 fragment of peloruside A that is both highly
stereoselective and efficient is described. Achieving an overall yield of 23% over 14 steps …

This is a review of papers published in the year 2015 that focus on the synthesis, reactivity,
or properties of compounds containing a carbon-transition metal double or triple bond …

The first method to access unsymmetrical aliphatic acyloins is presented. The method relies
on a fast 1, 3‐hydride shift mediated by an IrIII complex in allylic alcohols followed by …