An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …
effectiveness, ease of administration, and high patient compliance. However, the absorption …
Current approaches in lipid-based nanocarriers for oral drug delivery
M Plaza-Oliver, MJ Santander-Ortega… - Drug Delivery and …, 2021 - Springer
Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral
bioavailability because of their remarkable advantages like low toxicity, affordable scale-up …
bioavailability because of their remarkable advantages like low toxicity, affordable scale-up …
Oral delivery of biologics for precision medicine
The emerging field of precision medicine is rapidly growing, fostered by the advances in
genome mapping and molecular diagnosis. In general, the translation of these advances …
genome mapping and molecular diagnosis. In general, the translation of these advances …
Overcoming the intestinal barrier: a look into targeting approaches for improved oral drug delivery systems
Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …
Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules
Oral ingestion remains as the most convenient route of administration for the application of
pharmaceuticals since it is non-invasive and does not require trained personnel to …
pharmaceuticals since it is non-invasive and does not require trained personnel to …
Nonalcoholic fatty liver disease: current therapies and future perspectives in drug delivery
Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of the adult population
worldwide. This pathology can progress into end-stage liver disease with life-threatening …
worldwide. This pathology can progress into end-stage liver disease with life-threatening …
Local delivery of macromolecules to treat diseases associated with the colon
Current treatments for intestinal diseases including inflammatory bowel diseases, irritable
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …
compliance of the patient. Oral nanomedicines have been developed to overcome the …
[HTML][HTML] A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
V Marotti, Y Xu, CB Michalowski, W Zhang… - Bioactive materials, 2024 - Elsevier
Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-
inflammatory products. In this study, we sought to induce the physiological secretion of …
inflammatory products. In this study, we sought to induce the physiological secretion of …
Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD2-G
A Mwema, P Bottemanne, A Paquot, B Ucakar… - … , Biology and Medicine, 2023 - Elsevier
Here, prostaglandin D 2-glycerol ester (PGD 2-G) was selected to target neuroinflammation.
As PGD 2-G is reported to have a short plasmatic half-life, we propose to use lipid …
As PGD 2-G is reported to have a short plasmatic half-life, we propose to use lipid …