An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

Current approaches in lipid-based nanocarriers for oral drug delivery

M Plaza-Oliver, MJ Santander-Ortega… - Drug Delivery and …, 2021 - Springer
Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral
bioavailability because of their remarkable advantages like low toxicity, affordable scale-up …

Oral delivery of biologics for precision medicine

M Durán‐Lobato, Z Niu, MJ Alonso - Advanced Materials, 2020 - Wiley Online Library
The emerging field of precision medicine is rapidly growing, fostered by the advances in
genome mapping and molecular diagnosis. In general, the translation of these advances …

Overcoming the intestinal barrier: a look into targeting approaches for improved oral drug delivery systems

Y Xu, N Shrestha, V Préat, A Beloqui - Journal of controlled release, 2020 - Elsevier
Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …

Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules

MM Abeer, P Rewatkar, Z Qu, M Talekar, F Kleitz… - Journal of Controlled …, 2020 - Elsevier
Oral ingestion remains as the most convenient route of administration for the application of
pharmaceuticals since it is non-invasive and does not require trained personnel to …

Nonalcoholic fatty liver disease: current therapies and future perspectives in drug delivery

I Domingues, IA Leclercq, A Beloqui - Journal of Controlled Release, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of the adult population
worldwide. This pathology can progress into end-stage liver disease with life-threatening …

Local delivery of macromolecules to treat diseases associated with the colon

A Bak, M Ashford, DJ Brayden - Advanced drug delivery reviews, 2018 - Elsevier
Current treatments for intestinal diseases including inflammatory bowel diseases, irritable
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …

[HTML][HTML] A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment

V Marotti, Y Xu, CB Michalowski, W Zhang… - Bioactive materials, 2024 - Elsevier
Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-
inflammatory products. In this study, we sought to induce the physiological secretion of …

Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD2-G

A Mwema, P Bottemanne, A Paquot, B Ucakar… - … , Biology and Medicine, 2023 - Elsevier
Here, prostaglandin D 2-glycerol ester (PGD 2-G) was selected to target neuroinflammation.
As PGD 2-G is reported to have a short plasmatic half-life, we propose to use lipid …