This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

From a structural perspective, the predominant glial cell of the central nervous system, the
astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the …

Resistance arteries and downstream arterioles in the peripheral microcirculation contribute
substantially to peripheral vascular resistance, control of blood pressure, the distribution of …

Chronic obstructive pulmonary disease (COPD) is a disease characterised by persistent
airflow limitation that is not fully reversible and is currently the fourth leading cause of death …

Subarachnoid hemorrhage (SAH) is a devastating stroke subtype with a high rate of
mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of …

The tight spatial and temporal coupling between neuronal activity and blood flow ensures
that active brain regions receive an adequate supply of oxygen and energetic metabolites …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Biological tissues are fed by arterial networks whose task is to set blood flow delivery in
accordance with energetic demand. Coordinating vasomotor activity among hundreds of …