Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Since the 1990s, ionotropic glutamate receptors have served as an outstanding target for
drug discovery research aimed at the discovery of new neurotherapeutic agents. With the …

Kainate receptors belong to the family of ionotropic glutamate receptors. These receptors
assemble from five subunits (GluK1-5) into tetrameric ion channels. Kainate receptors are …

A library of six selenorhodamine dyes (4-Se–9-Se) were synthesized, characterized, and
evaluated as photosensitizers of TiO2 in dye-sensitized solar cells (DSSCs). The dyes were …

The kainate receptors GluK1‐3 (glutamate receptor ionotropic, kainate receptors 1–3)
belong to the family of ionotropic glutamate receptors and are essential for fast excitatory …

A KO t Bu-promoted [4+ 2] annulation-dehydration cascade reaction has been developed,
enabling the efficient synthesis of diverse 2-pyridone-fused uracils through a vinylogous …

Pyrimidine derivatives possess a high degree of application in many areas of chemistry such
as bioorganic, agricultural and medicinal chemistry. They are present in a broad range of …

Starting from 1–4 and 7 structural templates, analogues based on bioisosteric replacements
(5a–c vs 1, 2 and 6 vs 7) were synthesized for completing the SAR analysis. Interesting …

The influenza nucleoprotein (NP) is a single-strand RNA-binding protein and the core of the
influenza ribonucleoprotein (RNP) particle that serves many critical functions for influenza …

Among the ionotropic glutamate receptors, the physiological role of kainate receptors is less
well understood. Although ligands with selectivity toward the kainate receptor subtype GluK1 …