The influence of the microbiome on respiratory health

TP Wypych, LC Wickramasinghe, BJ Marsland - Nature immunology, 2019 - nature.com
The revolution in microbiota research over the past decade has provided invaluable
knowledge about the function of the microbial species that inhabit the human body. It has …

[HTML][HTML] Factors influencing the gut microbiota, inflammation, and type 2 diabetes

L Wen, A Duffy - The Journal of nutrition, 2017 - Elsevier
The gut microbiota is a complex community of bacteria residing in the intestine. Animal
models have demonstrated that several factors contribute to and can significantly alter the …

Primer, pipelines, parameters: issues in 16S rRNA gene sequencing

I Abellan-Schneyder, MS Matchado, S Reitmeier… - Msphere, 2021 - Am Soc Microbiol
Short-amplicon 16S rRNA gene sequencing is currently the method of choice for studies
investigating microbiomes. However, comparative studies on differences in procedures are …

Host genetic variation impacts microbiome composition across human body sites

R Blekhman, JK Goodrich, K Huang, Q Sun… - Genome biology, 2015 - Springer
Background The composition of bacteria in and on the human body varies widely across
human individuals, and has been associated with multiple health conditions. While microbial …

Interactions between intestinal microbiota and host immune response in inflammatory bowel disease

M Zhang, K Sun, Y Wu, Y Yang, P Tso… - Frontiers in …, 2017 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract. Although the etiology and pathogenesis of IBD remain unclear, both genetic …

The keystone-pathogen hypothesis

G Hajishengallis, RP Darveau, MA Curtis - Nature Reviews …, 2012 - nature.com
Recent studies have highlighted the importance of the human microbiome in health and
disease. However, for the most part the mechanisms by which the microbiome mediates …

Citrobacter rodentium: infection, inflammation and the microbiota

JW Collins, KM Keeney, VF Crepin… - Nature Reviews …, 2014 - nature.com
Citrobacter rodentium is a mucosal pathogen of mice that shares several pathogenic
mechanisms with enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli …

[HTML][HTML] Gut microbiota in health and disease

I Sekirov, SL Russell, LCM Antunes… - Physiological …, 2010 - journals.physiology.org
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the
mammalian gastrointestinal tract. The composition of this microbial community is host …

Mucin dynamics and enteric pathogens

MA McGuckin, SK Lindén, P Sutton… - Nature Reviews …, 2011 - nature.com
The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the
vast numbers of microorganisms that live in the healthy gut. Mucin glycoproteins are the …

The evolution of stomach acidity and its relevance to the human microbiome

DAE Beasley, AM Koltz, JE Lambert, N Fierer… - PloS one, 2015 - journals.plos.org
Gastric acidity is likely a key factor shaping the diversity and composition of microbial
communities found in the vertebrate gut. We conducted a systematic review to test the …