Mechanical feedback controls the emergence of dynamical memory in growing tissue monolayers

S Sinha, X Li, R Das, D Thirumalai - The Journal of Chemical Physics, 2022 - pubs.aip.org
The growth of a tissue, which depends on cell–cell interactions and biologically relevant
processes such as cell division and apoptosis, is regulated by a mechanical feedback …

[HTML][HTML] Self-generated persistent random forces drive phase separation in growing tumors

S Sinha, D Thirumalai - The Journal of Chemical Physics, 2020 - pubs.aip.org
A single solid tumor, composed of nearly identical cells, exhibits heterogeneous dynamics.
Dynamics of cells in the core is glass-like, whereas those in the periphery undergoes …

Interparticle Adhesion Regulates the Surface Roughness of Growing Dense Three-Dimensional Active Particle Aggregates

S Sinha, AN Malmi-Kakkada - The Journal of Physical Chemistry …, 2021 - ACS Publications
Activity and self-generated motion are fundamental features observed in many living and
nonliving systems. Given that interparticle adhesive forces can regulate particle dynamics …

Statistical Mechanical theory for spatio-temporal evolution of Intra-tumor heterogeneity in cancers: Analysis of Multiregion sequencing data

S Sinha, X Li, D Thirumalai - bioRxiv, 2022 - biorxiv.org
Variations in characteristics from one region (sub-population) to another is commonly
observed in complex systems, such as glasses and a collection of cells. Such variations are …